Interaction of diethyl aniline methylphosphonate with DNA: Spectroscopic and isothermal titration calorimetry

► The interaction of DAM with ct-DNA is a static enhancing type. ► DAM can slide into the G-C rich region of ct-DNA. ► The binding of DAM to ct-DNA is enthalpy controlled. ► The hydrogen bonding forces play an essential role in the binding process.