کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
540355 | 871311 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differentiating stem cells on patterned substrates for neural network formation
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
سخت افزارها و معماری
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چکیده انگلیسی
Both 3D topographic and 2D adhesive network patterns were used to guide the growth and differentiation of embryonic and mesenchymal stem cells towards a neurogenic lineage. In the case of topographic patterns, lattices composed of square micro-wells for single cell trapping combined with connection channels for neurite outgrowth guidance were designed, with optimal conditions being obtained with large well sizes and short channel lengths. In the case of adhesive micro-contact printed patterns, a similar network design can be applied, but the “well” size should be significantly smaller. Our results also proved the neuron-like characteristics of the induced cellular networks.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microelectronic Engineering - Volume 88, Issue 8, August 2011, Pages 1707–1710
Journal: Microelectronic Engineering - Volume 88, Issue 8, August 2011, Pages 1707–1710
نویسندگان
ChunXiong Luo, Li Liu, XiaoFang Ni, Li Wang, Shinichiro M. Nomura, Qi Ouyang, Yong Chen,