کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5408891 | 1506541 | 2017 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Solubility and thermodynamic/solvation behavior of 6-phenyl-4,5-dihydropyridazin-3(2H)-one in different (Transcutol + water) mixtures
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Pyridazinone derivatives are useful cardiovascular drugs which suffer from weak aqueous solubility and toxicity problems. Hence, in this work, the solubility of pyridazinone derivative i.e. 6-phenyl-4,5-dihydropyridazin-3(2H)-one (PDP-6) was measured in various “2-(2-ethoxyethoxy)ethanol (Transcutol®) + water” mixtures at temperatures “T = 293.2 K to 313.2 K and pressure “p = 0.1 MPa”. The experimental solubilities of PDP-6 were correlated with “Apelblat, Van't Hoff and Yalkowsky models” in terms of mean percent deviations and coefficient of determination. The highest solubilities of PDP-6 as mole fraction were obtained in pure Transcutol (5.27 Ã 10â 1 at T = 313.2 K). However, the lowest one was obtained in pure water (7.45 Ã 10â 7 at T = 293.2 K). “Apparent thermodynamic analysis” of solubilities of PDP-6 as mole fraction indicated an “endothermic dissolution” of PDP-6 in all “Transcutol + water” mixtures due to its positive values. “Enthalpy-entropy compensation” analysis indicated that the solvation of PDP-6 was “enthalpy-driven” in all “Transcutol + water” mixtures evaluated. Based on the results of the current study, PDP-6 has been proposed as practically insoluble in water and very soluble in Transcutol at T = 298.2 K.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Liquids - Volume 230, March 2017, Pages 511-517
Journal: Journal of Molecular Liquids - Volume 230, March 2017, Pages 511-517
نویسندگان
Faiyaz Shakeel, Mohd. Imran, Abida Abida, Nazrul Haq, Fars K. Alanazi, Ibrahim A. Alsarra,