کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5410470 | 1506557 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Solubility and thermodynamics of tenoxicam in (PEG-400Â +Â water) binary solvent systems at different temperatures
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this study, the solubility and thermodynamics of an anti-inflammatory drug tenoxicam (TNX) in various [polyethylene glycol-400 (PEG-400) + water] binary solvent systems was measured at temperatures T = (298.15 to 323.15) K and pressure p = 0.1 MPa. The solubilities of TNX were measured by an isothermal method and correlated with calculated ones. The mole fraction solubility of TNX was recorded highest in neat PEG-400 (3.50 Ã 10â 2 at T = 323.15 K) and lowest in neat water (4.13 Ã 10â 6 at T = 298.15 K) over the entire temperature range investigated. Thermodynamic studies on solubility of TNX indicated an endothermic, spontaneous and entropy driven dissolution behavior of TNX in all binary solvent systems investigated. The solubility experimental data of this research work could be useful in preformulation studies and formulation development of TNX.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Liquids - Volume 213, January 2016, Pages 221-227
Journal: Journal of Molecular Liquids - Volume 213, January 2016, Pages 221-227
نویسندگان
Faiyaz Shakeel, Nazrul Haq, Fars K. Alanazi, Ibrahim A. Alsarra,