Influence of molecular structure on the micellar and interfacial behavior of binary mixtures of amphiphilic drugs and polyoxyethylene ethers

► Interactions between amphiphilic drugs and nonionic surfactants have been studied. ► Strong synergistic interactions have been found between the components. ► Temperature helps in tuning the aggregational behavior of drug and its mixtures. ► Steric factor plays an important role in depicting the stability of the mixtures.