Influence of acetaminophen on gas hold-up, liquid circulation velocity and mass transfer coefficient in a split-cylinder airlift bioreactor

► The gas hold-up and overall oxygen transfer coefficient increased with increasing the gas velocity. ► The specific interfacial area increased and liquid-side oxygen transfer coefficient decreased with increasing gas velocity. ► The gas hold-up increased and bubble diameters decreased with acetaminophen addition. ► The overall oxygen transfer coefficient and gas hold-up increased with increasing acetaminophen concentration. ► Two correlations based on the dimensionless numbers were developed to find Sherwood number and gas hold-up.