کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5412938 | 1393457 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Kinetic study of Chondroitin Sulphate release from Chondroitin Sulphate/Chitosan complex hydrogel
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Kinetic study of Chondroitin Sulphate release from Chondroitin Sulphate/Chitosan complex hydrogel Kinetic study of Chondroitin Sulphate release from Chondroitin Sulphate/Chitosan complex hydrogel](/preview/png/5412938.png)
چکیده انگلیسی
Hydrogels based on complexes of Chitosan/Chondroitin Sulphate (CT/CS) can be formed just by mixing and have been applied as devices for CS releasing. In the CT/CS complex investigated in this work, the release of CS occurs mainly at pHs higher than 6.5, the value of pKaCT, and the maximum fraction of CS released is close to 0.5. In this work, the release of CS was treated as a diffusional transport process and as a partition phenomenon in which a partitioning of solutes between the solvent phase and the hydrogel phase occurs. Mathematical models for predicting the in vitro CS release profile from CT/CS polymer network were used. The hydrogel showed to be pH-responsive and values of half-time for CS releasing are compatibles for the application of CT/CS hydrogels in pharmacological field as devices for CS controlled release.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Liquids - Volume 156, Issue 1, 15 September 2010, Pages 28-32
Journal: Journal of Molecular Liquids - Volume 156, Issue 1, 15 September 2010, Pages 28-32
نویسندگان
Juliana F. Piai, LaÃs C. Lopes, André R. Fajardo, Adley F. Rubira, Edvani C. Muniz,