کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5413255 | 1506621 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thermodynamic studies on the interactions of phenyl salicylate in protic solvents at different temperatures
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Phenyl salicylate (PS) is employed as a nervous system depressant as well as an intestinal antiseptic owing to its antibacterial activity upon hydrolysis in the small intestine. The study of changes in its physico-chemical properties in different solvents may be helpful in understanding the mechanism of the drug action at physiological body temperatures. The partial molar quantities, namely, apparent molar volume (VÏ), partial molar volume (Vm°), thermal expansion coefficient (α2) and partial molar expansivity (E20) of phenyl salicylate in various protic solvents (i.e. methanol, ethanol, 1-propanol, 2-propanol, 1-butanol and 2-butanol at T = 293.15 K-313.15 K have been determined. The density and viscosity data in a molality range of 9.4 Ã 10â 3-3.1 Ã 10â 2 mol/kg are obtained with the help of commercially available vibrating tube densimeter and viscometer, respectively. The variation in the volumetric parameters resulting due to changes in temperature and the nature of solvents are explained on the basis of the drug-solvent hydrogen bonding, dielectric constant and dipole moments of the solvents used. The viscosity data is analyzed by the Jones-Dole equation and the derived viscosity B-coefficient is interpreted in terms of drug-solvent interactions. The molar Gibbs free energy âG20#, enthalpy ÎH20# and entropy ÎS20# of activation for viscous flow in various protic solvents are determined using the transition state theory of solutions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Liquids - Volume 143, Issues 2â3, 20 October 2008, Pages 75-80
Journal: Journal of Molecular Liquids - Volume 143, Issues 2â3, 20 October 2008, Pages 75-80
نویسندگان
Muhammad Javed Iqbal, Mansoora Ahmed Chaudhry,