کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5416854 | 1506895 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Macrodipoles of potassium and chloride ion channels as revealed by electronic structure calculations
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
With the aid of quantum mechanical calculations we investigate the electronic structure of the full length (FL) potassium channel protein, FL-KcsA, in its closed conformation, and the electronic structure of the ClC chloride channel. The results indicate that both ion channels are strongly polarized towards the extracellular region with respect to the membrane mean plane. FL-KcsA possesses an electric dipole moment of magnitude 403Â D while ClC has a macrodipole whose magnitude is about five times larger, 1983Â D, thereby contributing to differentiate their membrane electric barriers. The dipole vectors of both proteins are aligned along the corresponding n-fold axes. These results suggest that potassium and chloride ion channels are not passive with respect to the movement of ions across the membrane and the ionic motion driven by the electrochemical potential of the membrane might be affected by the electric field of the protein.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure: THEOCHEM - Volume 950, Issues 1â3, 30 June 2010, Pages 79-82
Journal: Journal of Molecular Structure: THEOCHEM - Volume 950, Issues 1â3, 30 June 2010, Pages 79-82
نویسندگان
Fabio Pichierri,