کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5431459 1398020 2016 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bioactive polymeric scaffolds for tissue engineering
ترجمه فارسی عنوان
داربست دار پلیمری برای مهندسی بافت
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی


- The requirements for an ideal biomaterial-based scaffold are highlighted.
- The relationship between mechanical properties and porosity is discussed.
- Several scaffold fabrication techniques are discussed with advantages and disadvantages.
- Examples of tissue engineering strategies provided

A variety of engineered scaffolds have been created for tissue engineering using polymers, ceramics and their composites. Biomimicry has been adopted for majority of the three-dimensional (3D) scaffold design both in terms of physicochemical properties, as well as bioactivity for superior tissue regeneration. Scaffolds fabricated via salt leaching, particle sintering, hydrogels and lithography have been successful in promoting cell growth in vitro and tissue regeneration in vivo. Scaffold systems derived from decellularization of whole organs or tissues has been popular due to their assured biocompatibility and bioactivity. Traditional scaffold fabrication techniques often failed to create intricate structures with greater resolution, not reproducible and involved multiple steps. The 3D printing technology overcome several limitations of the traditional techniques and made it easier to adopt several thermoplastics and hydrogels to create micro-nanostructured scaffolds and devices for tissue engineering and drug delivery. This review highlights scaffold fabrication methodologies with a focus on optimizing scaffold performance through the matrix pores, bioactivity and degradation rate to enable tissue regeneration. Review highlights few examples of bioactive scaffold mediated nerve, muscle, tendon/ligament and bone regeneration. Regardless of the efforts required for optimization, a shift in 3D scaffold uses from the laboratory into everyday life is expected in the near future as some of the methods discussed in this review become more streamlined.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioactive Materials - Volume 1, Issue 2, December 2016, Pages 93-108
نویسندگان
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