Probing the neutralization behavior of zwitterionic monomer-containing dental adhesive

- Dental adhesive containing zwitterionic monomer shows tuning neutralization rate.
- Resin exhibits faster photo-polymerization rate and higher conversion simultaneously.
- Polymer shows improved neutralization rate without compromised mechanical properties.

ObjectiveTo investigate the polymerization kinetics, neutralization behavior, and mechanical properties of amine-functionalized dental adhesive cured in the presence of zwitterionic monomer, methacryloyloxyethyl phosphorylcholine (MPC).MethodsThe control adhesive was a mixture based on HEMA/BisGMA/2-N-morpholinoethyl methacrylate (MEMA) (40/30/30, w/w/w). The control and experimental formulations containing MPC were characterized with regard to water miscibility of liquid resins, photopolymerization kinetics, water sorption and solubility, dynamic mechanical properties and leachables from the polymers (aged in ethanol). The neutralization behavior of the adhesives was determined by monitoring the pH of lactic acid (LA) solution.ResultsThe water miscibility decreased with increasing MPC amount. The water sorption of experimental copolymer specimen was greater than the control. The addition of 8 wt% water led to improved photo-polymerization efficiency for experimental formulations at MPC of 2.5 and 5 wt%, and significant reduction in the cumulative amounts of leached HEMA, BisGMA, and MEMA, i.e. 90, 60 and 50% reduction, respectively. The neutralization rate of MPC-containing adhesive was faster than control. The optimal MPC concentration in the formulations was 5 wt%.SignificanceIncompatibility between MEMA and MPC led to a decrease in water miscibility of the liquid resins. Water (at 8 wt%) in the MPC-containing formulations (2.5-5 wt% MPC) led to higher DC, faster RPmax and significant reduction in leached HEMA, BisGMA, and MEMA. The neutralization rate was enhanced with the addition of MPC in the amine-containing formulation. Promoting the neutralization capability of dentin adhesives could play an important role in reducing recurrent decay at the composite/tooth interface.

117