کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5477638 | 1399229 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of iodine supply on the radiation-induced DNA-fragmentation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی انرژی
انرژی هسته ای و مهندسی
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چکیده انگلیسی
Both cell types showed distinct ability for apoptosis as proven with camptothecin. The addition of “cold” iodine from 1 to 15 μg/ml without irradiation (“negative control”) did not change the response in both cell types. Plausibly, the radio-sensitivity of both cell types did increase markedly with increasing radiation dose but the radiation effect is diminished if iodine is added to the thyroid cells beforehand. The DNA-damage in thyroid cells after addition of cold iodine is reduced by a factor of 2-3. The skin cells did not show an significant change of radio-sensitivity depending on the presence of cold iodine. Elementary iodine possibly acts as a radical scavenger and thus markedly reduces the secondary radiation damage caused by the formation of cytotoxic radicals. This intrinsic radioprotective effect of iodine is seen only in cells with NIS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Environmental Radioactivity - Volume 166, Part 1, January 2017, Pages 157-161
Journal: Journal of Environmental Radioactivity - Volume 166, Part 1, January 2017, Pages 157-161
نویسندگان
F. Sudbrock, A. Herrmann, T. Fischer, B. Zimmermanns, W. Baus, A. Drzezga, K. Schomäcker,