کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5485709 | 1399437 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
More Than Bubbles: Creating Phase-Shift Droplets from Commercially Available Ultrasound Contrast Agents
ترجمه فارسی عنوان
بیشتر از حباب ها: ایجاد قطره های فاز تغییر از عوامل قراردادی کنتراست سونوگرافی قابل دسترس
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
آکوستیک و فرا صوت
چکیده انگلیسی
Phase-shift perfluorocarbon droplets have been investigated for over 20 years as pre-clinical ultrasound contrast agents with distinctive advantages in imaging and therapy. A number of formulation strategies exist, each with inherent advantages and limitations. In this note, we demonstrate a unique opportunity: that phase-shift droplets can be generated directly from commercially available microbubbles. This may facilitate pre-clinical and translational development by reducing the in-house synthesis expertise and resources required to generate high concentration droplet emulsions. Proof-of-principle in vitro and in vivo is given using droplets created from Definity and MicroMarker. The results demonstrate the role of perfluorocarbon choice in the trade-off between thermal stability and vaporization threshold, and suggest that commercial microbubbles with decafluorobutane cores may be ideal for this approach.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 43, Issue 2, February 2017, Pages 531-540
Journal: Ultrasound in Medicine & Biology - Volume 43, Issue 2, February 2017, Pages 531-540
نویسندگان
Paul S. Sheeran, Kimoon Yoo, Ross Williams, Melissa Yin, F. Stuart Foster, Peter N. Burns,