Assessment of micronecrotic tumor tissue using dynamic contrast-enhanced magnetic resonance imaging

The extended Tofts model overestimated the interstitial volume fraction by a median of 6.9% resp. 10.0% and the parallel 3-compartment model by 8.6% resp. 15.5%, while the sequential 3-compartment model overestimated it by 0.2% resp. underestimated it by 18.8% when simulating a mean vessel distance of 100 μm resp. 150 μm. Overall, the sequential 3-compartment model provided more reliable results both for the total fractional interstitial volume and for the interstitial subcompartments.