کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5501087 | 1534622 | 2017 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease
ترجمه فارسی عنوان
مسیرهای عصبی تولید مثل در چاقی، دیابت و بیماری آلزایمر
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کلمات کلیدی
Sirt1NACHT, LRR and PYD domains-containing protein 3NLRP3RAGETLR4AβIL1β - IL1bdocosahexaenoic acid - اسید داکوزاگزوائونیکinterleukin 1 beta - اینترلوکین 1 بتاamyloid beta - بتا آمیلوئیدAlzheimer's disease - بیماری آلزایمرDHA - دوکوساهگزائنوئیک اسیدBBB - سد خونی مغزیblood brain barrier - سد خونی مغزیAge - سنToll like receptor 4 - مانند گیرنده 4Advanced glycation end products - محصولات نهایی پیشرفته گلیساسیونReceptor for advanced glycation end products - گیرنده برای محصولات پیشرفته glycation پایان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Cognitive decline in chronic diabetic patients is a less investigated topic. Diabetes and obesity are among the modifiable risk factors for Alzheimer's disease (AD), the most common form of dementia. Studies have identified several overlapping neurodegenerative mechanisms, including oxidative stress, mitochondrial dysfunction, and inflammation that are observed in these disorders. Advanced glycation end products generated by chronic hyperglycemia and their receptor RAGE provide critical links between diabetes and AD. Peripheral inflammation observed in obesity leads to insulin resistance and type 2 diabetes. Although the brain is an immune-privileged organ, cross-talks between peripheral and central inflammation have been reported. Damage to the blood brain barrier (BBB) as seen with aging can lead to infiltration of immune cells into the brain, leading to the exacerbation of central inflammation. Neuroinflammation, which has emerged as an important cause of cognitive dysfunction, could provide a central mechanism for aging-associated ailments. To further add to these injuries, adult neurogenesis that provides neuronal plasticity is also impaired in the diabetic brain. This review discusses these molecular mechanisms that link obesity, diabetes and AD. This article is part of a Special Issue entitled: Oxidative Stress and Mitochondrial Quality in Diabetes/Obesity and Critical Illness Spectrum of Diseases - edited by P. Hemachandra Reddy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1863, Issue 5, May 2017, Pages 1037-1045
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1863, Issue 5, May 2017, Pages 1037-1045
نویسندگان
Subbiah Pugazhenthi, Limei Qin, P. Hemachandra Reddy,