کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5503754 | 1535596 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseases
ترجمه فارسی عنوان
پیری عروق و پیری سلول اندوتلیال: مکانیسم های مولکولی فیزیولوژی و بیماری
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Platelet-derived growth factor BBECN1p73pdgfbMIRHUVECBeclin1HIFs - HIF هاMitochondrial dysfunction - اختلال در عملکرد میتوکندریEndothelium - اندوتلیومTransglutaminase 2 - ترانس گلوتامیناز 2Oxidative stress - تنش اکسیداتیوp53 family - خانواده p53microRNAs - ریز آرانایHypoxia inducible factors - عوامل القایی هیپوکسیVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)MicroRNA - میکرو RNA Hypoxia - هیپوکسی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Ageing leads to a progressive deterioration of structure and function of all organs over the time. During this process endothelial cells undergo senescence and manifest significant changes in their properties, resulting in impairment of the vascular functionality and neo-angiogenic capability. This ageing-dependent impairment of endothelial functions is considered a key factor contributing to vascular dysfunctions, which is responsible of several age-related diseases of the vascular system and other organs. Several mechanisms have been described to control ageing-related endothelial cell senescence including microRNAs, mitochondrial dysfunction and micro environmental stressors, such as hypoxia. In this review, we attempt to summarize the recent literature in the field, discussing the major mechanisms involved in endothelial cell senescence. We also underline key molecular aspects of ageing-associated vascular dysfunction in the attempt to highlight potential innovative therapeutic targets to delay the onset of age-related diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 159, October 2016, Pages 14-21
Journal: Mechanisms of Ageing and Development - Volume 159, October 2016, Pages 14-21
نویسندگان
Carla Regina, Emanuele Panatta, Eleonora Candi, Gerry Melino, Ivano Amelio, Carmela Rita Balistreri, Margherita Annicchiarico-Petruzzelli, Nicola Di Daniele, Giovanni Ruvolo,