کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5504100 | 1400213 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hypoxia-induced increases in serotonin-immunoreactive nerve fibers in the medulla oblongata of the rat
ترجمه فارسی عنوان
افزایش هیپوکسی در الیاف عصبی سروتونین-ایمونوگرام در لانه گزینی مدولا موش صحرایی
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کلمات کلیدی
NK1RXIIrVRGSpVccaudal ventral respiratory groupcVRGPBCAMBRPAVRCSpViCVLMVLMSPIVVIIexternal cuneate nucleusRVLMnucleus raphe obscurusMedulla oblongataNTS5HTDMXDBHECUPARNrostral ventrolateral medulla - آرام آرامRespiration - تنفسPyramidal tract - دستگاه PyramidalSolitary tract - دستگاه تناسلیdopamine β-hydroxylase - دوپامین β-هیدروکسیلازVentral respiratory column - ستون فقرات تنشیSerotonin - سروتونینarea postrema - طبقه آخرLin - لینInferior olivary complex - مجتمع ایلواریا پایین ترBötzinger complex - مجموعه بوستینگرpre-Bötzinger complex - مجموعه پیش بتزینگرventrolateral medulla - مدول ونتیلاتورcaudal ventrolateral medulla - مدولال ventrolateral کادالcuneate nucleus - هسته cuneatehypoglossal nucleus - هسته hypoglossalnucleus ambiguus - هسته ابهامmedial vestibular nucleus - هسته داخلی وادیnucleus of the solitary tract - هسته دستگاه انفرادیnucleus raphe magnus - هسته رافا مگنnucleus raphe pallidus - هسته رافا پالیدوسGigantocellular reticular nucleus - هسته مجلسی گیگانت سلولیDorsal motor nucleus of the vagus nerve - هسته موتور پشتی عصب واگspinal vestibular nucleus - هسته ویستیبال ستون فقراتfacial nucleus - هسته چهرهHypoxia - هیپوکسیrostral ventral respiratory group - گروه تنفسی شکمی روسترولGRN - گرینNeurokinin 1 receptor - گیرنده neurokinin 1
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Hypoxia induces respiratory responses in mammals and serotonergic neurons in the medulla oblongata participate in respiratory control. However, the morphological changes in serotonergic neurons induced by hypoxia have not yet been examined and respiratory controls of serotonergic neurons have not been clarified. We herein investigated the distribution of immunoreactivity for serotonin (5-hydroxytryptamine; 5-HT) in the medulla oblongata of control rats and rats exposed to 1-6 h of hypoxia (10% O2). We also examined the medulla oblongata by multiple immunofluorescence labeling for 5-HT, neurokinin 1 receptors (NK1R), a marker for some respiratory neurons in the pre-Bötzinger complex (PBC), and dopamine β-hydroxylase (DBH), a marker for catecholaminergic neurons. The number of 5-HT-immunoreactive nerve cell bodies in the raphe nuclei was higher in rats exposed to hypoxia than in control rats. The number of 5-HT-immunoreactive nerve fibers significantly increased in the rostral ventrolateral medulla of rats exposed to 1-6 h of hypoxia, caudal ventrolateral medulla of rats exposed to 2-6 h of hypoxia, and lateral part of the nucleus of the solitary tract and dorsal motor nucleus of the vagus nerve of rats exposed to 1-2 h of hypoxia. Multiple immunofluorescence labeling showed that 5-HT-immunoreactive nerve fibers were close to NK1R-immunoreactive neurons in ventrolateral medulla and to DBH-immunoreactive neurons in the medulla. These results suggest that serotonergic neurons partly regulate respiratory control under hypoxic conditions by modulating the activity of NK1R-expressing and catecholaminergic neurons.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 118, Issue 8, October 2016, Pages 806-817
Journal: Acta Histochemica - Volume 118, Issue 8, October 2016, Pages 806-817
نویسندگان
Ryosuke Morinaga, Nobuaki Nakamuta, Yoshio Yamamoto,