کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5505459 1400270 2017 26 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Airborne polycyclic aromatic hydrocarbons trigger human skin cells aging through aryl hydrocarbon receptor
ترجمه فارسی عنوان
هیدروکربن های آروماتیک چند حلقه ای هوابرد باعث سلول های پوستی انسان می شوند که از طریق گیرنده های آرویل هیدروکربن پیر می شوند
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Accumulating evidence suggests that polycyclic aromatic hydrocarbons (PAH) which adsorbed on the surface of ambient air particulate matters (PM), are the major toxic compound to cause cardiovascular and respiratory diseases, even cancer. However, its detrimental effects on human skin cell remain unclear. Here, we demonstrated that SRM1649b, a reference urban dust material of PAH, triggers human skin cells aging through cell cycle arrest, cell growth inhibition and apoptosis. Principally, SRM1649b facilitated Aryl hydrocarbon receptor (AhR) translocated into nucleus, subsequently activated ERK/MAPK signaling pathway, and upregulated aging-related genes expression. Most important, we found that AhR antagonist efficiently revert the aging of skin cells. Thus our novel findings firstly revealed the mechanism of skin aging under PAH contamination and provided potential strategy for clinical application.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 488, Issue 3, 1 July 2017, Pages 445-452
نویسندگان
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