Compound 21 and Telmisartan combination mitigates type 2 diabetic nephropathy through amelioration of caspase mediated apoptosis

An inhibition of AT1R, and simultaneous activation of AT2R using Telmisartan and Compound 21 reduces oxidative stress, hypertension, NF-κ mediated renal inflammation and caspase mediated apoptosis, which could be partly attributed to its ability to regulate PCAF and histone H3 acetylation.236