کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5505712 | 1400276 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Functional characterization of archaeal homologs of human nuclear RNase P proteins Rpp21 and Rpp29 provides insights into the molecular basis of their cooperativity in catalysis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Functional characterization of archaeal homologs of human nuclear RNase P proteins Rpp21 and Rpp29 provides insights into the molecular basis of their cooperativity in catalysis Functional characterization of archaeal homologs of human nuclear RNase P proteins Rpp21 and Rpp29 provides insights into the molecular basis of their cooperativity in catalysis](/preview/png/5505712.png)
چکیده انگلیسی
A mechanistic model for the synergistic activation of PhopRNA by PhoRpp21 and PhoRpp29. PhoRpp21 binds to the loop between P11 and P12 helices in PhopRNA and serves as a scaffold for PhoRpp29 to optimize a structural conformation of a positively charged edge composed of lysine residues (â) at α2 in PhoRpp21and C-terminal residues (â) in PhoRpp29 on the protein complex which probably stabilize stacking interactions between PhopRNA and pre-tRNA. â² indicates the processing site in pre-tRNA.181
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 482, Issue 1, 1 January 2017, Pages 68-74
Journal: Biochemical and Biophysical Research Communications - Volume 482, Issue 1, 1 January 2017, Pages 68-74
نویسندگان
Dan Jiang, Kenta Izumi, Toshifumi Ueda, Kosuke Oshima, Takashi Nakashima, Makoto Kimura,