کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5506446 1400295 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanistic insight into neurotoxicity induced by developmental insults
ترجمه فارسی عنوان
بینش مکانیکی به عصبی ناشی از انحرافات رشد
کلمات کلیدی
عصبی عصبی، سلول های بنیادی عصبی، مرگ سلولی و تمایز،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Epidemiological and/or experimental studies have shown that unfavorable prenatal environmental factors, such as stress or exposure to certain neurotoxic environmental contaminants, may have adverse consequences for neurodevelopment. Alterations in neurogenesis can have harmful effects not only for the developing nervous system, but also for the adult brain where neurogenesis is believed to play a role in learning, memory, and even in depression. Many recent advances in the understanding of the complex process of nervous system development can be integrated into the field of neurotoxicology. In the past 15 years we have been using cultured neural stem or progenitor cells to investigate the effects of neurotoxic stimuli on cell survival, proliferation and differentiation, with special focus on heritable effects. This is an overview of the work performed by our group in the attempt to elucidate the mechanisms of developmental neurotoxicity and possibly provide relevant information for the understanding of the etiopathogenesis of complex brain disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 482, Issue 3, 15 January 2017, Pages 408-418
نویسندگان
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