کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5507260 | 1400322 | 2017 | 44 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synchronism in mitochondrial ROS flashes, membrane depolarization and calcium sparks in human carcinoma cells
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کلمات کلیدی
MPTPΔΨmDCF-DATMRMCa2 + sparksROS - ROSmitochondrial ROS - ROS میتوکندریmitochondrial permeability transition pore - انتقال نفوذی میتوکندری منفی استSOD - سدCarcinoma cells - سلولهای سرطانیSuperoxide dismutase - سوکسوکس دیسموتازtetramethylrhodamine methyl ester - متیل استر تترامتیل رودامینMitochondria - میتوکندریاMembrane potential - پتانسیل غشاء Mitochondrial membrane potential - پتانسیل غشای میتوکندریReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Mitochondria are major producers of reactive oxygen species (ROS) in many cells including cancer cells. However, complex interrelationships between mitochondrial ROS (mitoROS), mitochondrial membrane potential (ÎΨm) and Ca2 + are not completely understood. Using human carcinoma cells, we further highlight biphasic ROS dynamics: - gradual mitoROS increase followed by mitoROS flash. Also, we demonstrate heterogeneity in rates of mitoROS generation and flash initiation time. Comparing mitochondrial and near-extra-mitochondrial signals, we show that mechanisms of mitoROS flashes in single mitochondria, linked to mitochondrial permeability transition pore opening (ÎΨm collapse) and calcium sparks, may involve flash triggering by certain levels of external ROS released from the same mitochondria. In addition, mitochondria-mitochondria interactions can produce wave propagations of mitoROS flashes and ÎΨm collapses in cancer cells similar to phenomena of ROS-induced ROS release (RIRR). Our data suggest that in cancer cells RIRR, activation of mitoROS flashes and mitochondrial depolarization may involve participation of extramitochondrial-ROS produced either by individual mitochondria and/or by neighboring mitochondria. This could represent general mechanisms in ROS-ROS signaling with suggested role in both mitochondrial and cellular physiology and signaling.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics - Volume 1858, Issue 6, June 2017, Pages 418-431
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics - Volume 1858, Issue 6, June 2017, Pages 418-431
نویسندگان
Andrey V. Kuznetsov, Sabzali Javadov, Valdur Saks, Raimund Margreiter, Michael Grimm,