کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5508682 1400395 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Orphan proteins of unknown function in the mitochondrial intermembrane space proteome: New pathways and metabolic cross-talk
ترجمه فارسی عنوان
پروتئین های یتیم از عملکرد ناشناخته در پروتئوم فضای میان مخروطی میتوکندری: مسیرهای جدید و متقابل صحبت متقابل
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


- A brief overview of the classic mitochondrial import pathways is featured
- Recent studies assigning a number of new proteins to the mitochondrial IMS are discussed
- Analysis of the expanded IMS proteomes can provide insights into organelle cross-talk and signalling pathways

The mitochondrial intermembrane space (IMS) is involved in protein transport, lipid homeostasis and metal ion exchange, while further acting in signalling pathways such as apoptosis. Regulation of these processes involves protein modifications, as well as stress-induced import or release of proteins and other signalling molecules. Even though the IMS is the smallest sub-compartment of mitochondria, its redox state seems to be tightly regulated. However, the way in which this compartment participates in the cross-talk between the multiple organelles and the cytosol is far from understood. Here we focus on newly identified IMS proteins that may represent future challenges in mitochondrial research. We present an overview of the import pathways, the recently discovered new components of the IMS proteome and how these relate to key aspects of cell signalling and progress made in stem cell and cancer research.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1863, Issue 11, November 2016, Pages 2613-2623
نویسندگان
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