کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5526986 1547702 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MRTF-A-miR-206-WDR1 form feedback loop to regulate breast cancer cell migration
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
MRTF-A-miR-206-WDR1 form feedback loop to regulate breast cancer cell migration
چکیده انگلیسی


- WDR1 enhanced the effect of MRTF-A induced cell migration via RhoA-MRTF-A signaling pathway.
- WDR1 promoted the nuclear importion of MRTF-A.
- MRTF-A promoted the expression of miR-206 via its promoter CArG box.
- miR-206 inhibits cell migration through suppressing the expression of WDR1 and MRTF-A.
- MRTF-A-miR-206-WDR1 form feedback loop to regulate breast cancer cell migration.

Breast cancer is the leading cause of cancer death in women worldwide which is closely related to metastasis. Our previous study has shown that MRTF-A promote the migration of MDA-MB-231 cells and WDR1 promotes breast cancer cell migration. But the exact molecular mechanism on metastasis is still not fully understood, we now report that WDR1 enhanced the effect of MRTF-A induced-MDA-MB-231 cell migration by promoting the expression of the EMT markers and migration markers via RhoA-MRTF-A signaling pathway. Importantly, WDR1 promoted the nuclear importion of MRTF-A by affecting the expression of nuclear transport protein importin. But WDR1 did not affect the expression of MRTF-A. Interestingly, MRTF-A promoted the expression of miR-206 via its promoter CArG box but miR-206 inhibits the migration of breast cancer cells through suppressing the expression of WDR1 and MRTF-A via targeted their 3′UTR. Our data thus provide important and novel insights into MRTF-A-miR-206-WDR1 form feedback loop to regulate breast cancer cell migration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 359, Issue 2, 15 October 2017, Pages 394-404
نویسندگان
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