کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5527145 | 1401568 | 2017 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: PSME3 induces epithelial-mesenchymal transition with inducing the expression of CSC markers and immunosuppression in breast cancer PSME3 induces epithelial-mesenchymal transition with inducing the expression of CSC markers and immunosuppression in breast cancer](/preview/png/5527145.png)
- PSME3 induces the epithelial-mesenchymal transition in the MDA-MB-231 cell line.
- PSME3 promotes the migration, invasion, and proliferation of MDA-MB-231 cells.
- PSME3 induces the expression of CSC markers of the MDA-MB-231 cell line.
- PSME3 expression induces T-cell apoptosis and increases subcutaneous tumor growth.
Proteasome activator subunit 3 (PSME3) plays a key role in breast cancer by regulating the cell cycle. However, its role in other pathogenesis-related features of breast cancer is unclear. In this study, we found that overexpression of PSME3 induced the epithelial-mesenchymal transition and contributed to induce the expression of cancer stem cell markers of the MDA-MB-231 cell line, thus increasing the migration, and invasion of the cells. Moreover, overexpression of PSME3 reduced the chemotaxis of CD8+ T cells and induced the apoptosis of T cells in vitro. Furthermore, PSME3 knockdown increased the number of CD8+ T cells in vivo and reduced the subcutaneous tumor growth rate. These findings revealed that PSME3 induces epithelial-mesenchymal transition with inducing the expression of CSC markers and influencing the tumor immune microenvironment in breast cancer.
Journal: Experimental Cell Research - Volume 358, Issue 2, 15 September 2017, Pages 87-93