کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5529408 1401697 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articleThe synergistic effect between vanillin and doxorubicin in ehrlich ascites carcinoma solid tumor and MCF-7 human breast cancer cell line
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Original articleThe synergistic effect between vanillin and doxorubicin in ehrlich ascites carcinoma solid tumor and MCF-7 human breast cancer cell line
چکیده انگلیسی

Despite the remarkable anti-tumor activity of doxorubicin (DOX), its clinical application is limited due to multiple organ toxicities. Products with less side effects are therefore highly requested. The current study investigated the anti-cancer activities of vanillin against breast cancer and possible synergistic potentiation of DOX chemotherapeutic effects by vanillin. Vanillin (100 mg/kg), DOX (2 mg/kg) and their combination were administered i.p. to solid Ehrlich tumor-bearing mice for 21 days. MCF-7 human breast cancer cell line was treated with vanillin (1 and 2 mM), DOX (100 μM) or their combination. Protection against DOX-induced nephrotoxicity was studied in rats that received vanillin (100 mg/kg, ip) for 10 days with a single dose of DOX (15 mg/kg) on day 6. Vanillin exerted anticancer effects comparable to DOX and synergesticlly potentiated DOX anticancer effects both in-vivo and in-vitro. The anticancer potency of vanillin in-vivo was mediated via apoptosis and antioxidant capacity. It also offered an in-vitro growth inhibitory effect and cytotoxicity mediated by apoptosis (increased caspase-9 and Bax:Bcl-2 ratio) along with anti-metasasis effect. Vanillin protected against DOX-induced nephrotoxicity in rats. In conclusion, vanillin can be a potential lead molecule for the development of non-toxic agents for the treatment of breast cancer either alone or combined with DOX.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Research and Practice - Volume 212, Issue 9, September 2016, Pages 767-777
نویسندگان
, , , ,