کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5537406 | 1402333 | 2016 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An inflammatory response is essential for the development of adaptive immunity-immunogenicity and immunotoxicity
ترجمه فارسی عنوان
پاسخ التهابی برای توسعه ایمنی و ایمنی سازگار و سمی بودن ایمنی ضروری است
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
The humoral and cellular immune responses of adaptive immunity are induced following immunization with effective vaccines. They induce functional cytokines and chemokines through the binding of vaccine components or adjuvants to innate immune receptors. Alum-adjuvanted vaccines induce local inflammatory nodules at injection sites, and the systemic and local production of the inflammatory cytokines, IL-1β, IL-6, and TNF-α, has been reported to occur three hours after vaccinations. Furthermore, G-CSF levels increase at injection sites. Neutrophils initially migrate and neutrophil extracellular traps (NETs) then develop, which stimulate damage-associated molecular patterns (DAMPs), inducing inflammatory cytokines production. Approximately 10-15% of recipients of simultaneous immunizations with multiple vaccines develop febrile reactions, and have higher G-CSF levels. Innate immune responses following vaccinations are discussed herein.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 34, Issue 47, 11 November 2016, Pages 5815-5818
Journal: Vaccine - Volume 34, Issue 47, 11 November 2016, Pages 5815-5818
نویسندگان
Tetsuo Nakayama,