کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5545168 1555315 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of different oral oxytetracycline treatment regimes on selection of antimicrobial resistant coliforms in nursery pigs
ترجمه فارسی عنوان
تاثیر رژیمهای مختلف اکسایت تتراسایکلین خوراکی بر انتخاب کلیفرم های مقاوم به ضد میکروبی در خوک های پرورشگاه
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی
A major concern derived from using antimicrobials in pig production is the development of resistance. This study aimed to assess the impact of selected combinations of oral dose and duration of treatment with oxytetracycline (OTC) on selection of tetracycline resistant (TET-R) coliforms recovered from swine feces. The work encompassed two studies: 1) OTC 5 mg/kg and 20 mg/kg were administered to nursery pigs for 3 and 10 days, respectively, under controlled experimental conditions, and 2) 10 mg/kg, 20 mg/kg and 30 mg/kg OTC were given to a higher number of pigs for 6, 3 and 2 days, respectively, under field conditions. Statistical modeling was applied to analyze trends in the proportion of TET-R coliforms. In the experimental study, no statistical difference in proportion of TET-R coliforms was observed between treatments at the end of the trial (day 18) and compared to day 0. In the field study, treatment had a significant effect on the proportion of TET-R bacteria two days after the end of treatment (2dAT) with the regimes “low dose-six days” and “medium dose-three days” yielding the highest and lowest proportions of TET-R strains, respectively. No indication of co-selection for ampicillin- and sulphonamide -R bacteria was observed for any treatment at 2dAT. By the end of the nursery period, the proportion of TET-R bacteria was not significantly different between treatments and compared to day 0. Our results suggest that similar resistance levels might be obtained by using different treatment regimes regardless of the combinations of oral dose-duration of treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Microbiology - Volume 208, September 2017, Pages 1-7
نویسندگان
, , , , , ,