کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5545302 | 1555320 | 2017 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A bacterial ghost improves the immunological efficacy of a Newcastle disease virus inactivated vaccine
ترجمه فارسی عنوان
یک روح باکتری باعث بهبود عملکرد ایمنی یک واکسن غیرفعال شده از ویروس نیوکاسل می شود
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
چکیده انگلیسی
Newcastle disease (ND) is one of the most common contagious viral infectious diseases of poultry. Vaccination is an effective way to protect chickens from Newcastle disease virus (NDV), and large efforts have been made to acquire not only new vaccines but also new adjuvants to improve the efficiency of existing inactivated vaccines. Here, we observed the adjuvanticity of the bacterial ghost (BG) on the effectiveness of inactivated NDV vaccine in a chicken model. We found that BG, as an adjuvant with inactivated NDV vaccine, substantially strengthened the ND-specific antibody response and protection against lethal challenge in a chicken model, reduced viral shedding, strengthened the time duration of antibody titers, produced an available immunization effect with a low dose of vaccine, and improved serum IL-2 and IFN-γ concentrations. Our results demonstrate that BG significantly improved the immunogenicity of an inactivated NDV vaccine and is a new immune adjuvant candidate.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Microbiology - Volume 203, May 2017, Pages 189-195
Journal: Veterinary Microbiology - Volume 203, May 2017, Pages 189-195
نویسندگان
Wei Si, Shenye Yu, Henggui Liu, Chunlai Wang, Liping Chen, Gaoling Wang, Jianan Wu, Siguo Liu,