کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5545363 | 1555323 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impact of bacteriophage Saint3 carriage on the immune evasion capacity and hemolytic potential of Staphylococcus aureus CC398
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
Here, we analyzed with a set of S. aureus CC398 isolates harboring/lacking ÏSaint3 how this MGE affects (i) phagocytosis of CC398 isolates by polymorphonuclear neutrophils (PMNs), and (ii) hemolysis of human and livestock-derived erythrocytes. Isolates lacking ÏSaint3 were more efficiently phagocytosed by human PMNs in whole blood phagocytosis assays than isolates harboring this bacteriophage, irrespective of their origin. Notably, a similar effect was observed when equine blood was utilized, but not detected with porcine blood. Integration of ÏSaint3 into LA-MRSA CC398 strains lacking this MGE confirmed these findings, as ÏSaint3-harboring recipients were again less efficiently ingested by PMNs in equine and human blood than their parental strains. Integration of ÏSaint3 strongly reduced the hemolytic potential of the culture supernatants against human-derived erythrocytes, and to a smaller extent also against porcine-derived erythrocytes, while ÏSaint3 integration only slightly affected the hemolytic capacities against equine-derived red blood cells. The significant protective effect of ÏSaint3 against phagocytosis by equine PMNs suggests that the host specificity of the IEC components might be broader than currently assumed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Microbiology - Volume 200, February 2017, Pages 46-51
Journal: Veterinary Microbiology - Volume 200, February 2017, Pages 46-51
نویسندگان
Philipp Jung, Mohamed M.H. Abdelbary, Britta Kraushaar, Alexandra Fetsch, Jürgen Geisel, Mathias Herrmann, Wolfgang Witte, Christiane Cuny, Markus Bischoff,