کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5549552 1556734 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Investigation of the potential application of sodium bentonite as an excipient in formulation of sustained release tablets
ترجمه فارسی عنوان
بررسی کاربرد بالقوه بنتونیت سدیم به عنوان یک عصاره دهنده در فرمولاسیون تداخلات دارویی
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

In this study, the application of sodium bentonite (SB) in formulation of tablets prepared by direct compression for oral administration was tested. Three different model drugs with different solubilities: paracetamol, diclofenac sodium and metformin HCl were tested. Each drug was mixed with SB at ratio of 50% and the mixtures were subsequently compressed. Compatibility studies were conducted using both Deferential Scanning Calorimeter (DSC) and Fourier Transform Infrared Spectroscopy (FTIR). The dissolution profile for each drug was determined in USP-buffers at different time intervals. Diclofenac sodium in pH 6.8 buffer and paracetamol in both pH 6.8 and pH 4.5 buffers showed extended release. However, metformin HCl showed immediate release at the different pH values. The study showed that using SB was possible to prepare tablets with different release profiles. However, these profiles differ depending on dissolution media and drug type.

Graphical Abstract51

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Journal of Pharmaceutical Sciences - Volume 12, Issue 3, May 2017, Pages 259-265
نویسندگان
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