کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5549579 | 1556737 | 2016 | 9 صفحه PDF | دانلود رایگان |
To achieve GSH-responsive 5-Fluorouridine (5-FU) delivery, a novel family of nanogel drug carriers has been successfully prepared. The new class of PAHy-based nanogels was prepared by the crossing-link reaction of poly-α, β-polyasparthydrazide (PAHy) chains and 3,3â²-dithiodipropionic acid (DTDPA) consisting of a redox-responsive chain network. This particle highlights recent efforts in introducing a disulfide bond to drug delivery nanogel by DTDPA, and the increased release properties of complex nanogels produced excellent glutathione (GSH)-sensitivity and significant anti-tumor therapeutic efficacy. The PAHy-based nanogels were characterized by Fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS) (nano-particle size ~200ânm), UV-vis spectrometry, X-ray diffraction (XRD) and differential scanning calorimetric (DSC). PAHy-based nanogels are promising controlled-release carriers for the tumor-targeting delivery of the anticancer agent 5-Fluorouridine.
Graphical Abstract
Journal: Asian Journal of Pharmaceutical Sciences - Volume 11, Issue 6, December 2016, Pages 735-743