کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5549988 1557284 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Voriconazole-loaded nanostructured lipid carriers (NLC) for drug delivery in deeper regions of the nail plate
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Voriconazole-loaded nanostructured lipid carriers (NLC) for drug delivery in deeper regions of the nail plate
چکیده انگلیسی

Voriconazole-loaded nanostructured lipid carriers (VOR-NLC) were developed and drug penetration evaluated in porcine hooves in vitro. Synergistic effect of urea (Ur), selected among other known chemical enhancers according to hoof hydration potential, was also evaluated. VOR-NLC presented a high encapsulation efficiency (74.52 ± 2.13%), approximate mean diameter of 230 nm and were positively charged (+27.32 ± 2.74 mV). Stability studies indicated they were stable under refrigeration (4 ± 2 °C) for up to 150 days. SEM images revealed hooves treated with VOR-NLC and VOR-NLC-Ur suffered a disturbance on the surface depicting high roughness and porosity. Permeation data showed a substantial VOR amount retained in superficial hooves sections independent of the formulation used (2.42 ± 0.26; 2.52 ± 0.36 and 2.41 ± 0.60 μg/cm2 for unloaded VOR, VOR-NLC and VOR-NLC-Ur, respectively, p > 0.05). Still, successive extractions, revealed the amount of VOR retained in deeper regions was significantly higher when VOR-NLC or VOR-NLC-Ur was used (0.17 ± 0.04, 0.47 ± 0.14 and 0.36 ± 0.07 μg/cm2 for unloaded VOR, VOR-NLC and VOR-NLC-Ur, respectively, p < 0.05). Such results indicate NLC are promising formulations for the management of onychomycosis. Further studies in diseased nail plates are necessary.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 531, Issue 1, 5 October 2017, Pages 292-298
نویسندگان
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