کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5552504 | 1557947 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MTA1 expression in human cancers - Clinical and pharmacological significance
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کلمات کلیدی
MTAsPTERTSANuRDERαMBDMTA1SAHASERMEstradiol - استرادیولSuberoylanilide hydroxamic acid - اسید سدئروانیلید هیدروکسامDrug targets - اهداف مواد مخدرepithelial to mesenchymal transition - اپیتلیال به انتقال مزانشیمالTrichostatin A - تریکوستاتین AEMT - تکنسین فوریتهای پزشکیTumor metastasis - متاستاز تومورSelective estrogen receptor modulators - مدولاتور گیرنده استروژن انتخابیEpigenetic Gene Regulation - مقررات ژنی اپی ژنتیکیhistone deacetylases - هیستون deacetylasesPterostilbene - پتروستیلبنEstrogen receptor alpha - گیرنده استروژن آلفا
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Remarkably, majority of the cancer deaths are due to metastasis, not because of primary tumors. Metastasis is one of the important hallmarks of cancer. During metastasis invasion of primary tumor cells from the site of origin to a new organ occurs. Metastasis associated proteins (MTAs) are a small family of transcriptional coregulators that are closely associated with tumor metastasis. These proteins are integral components of nuclear remodeling and deacetylation complex (NuRD). By virtue of being integral components of NuRD, these proteins regulate the gene expression by altering the epigenetic changes such as acetylation and methylation on the target gene chromatin. Among the MTA proteins, MTA1 expression is very closely correlated with the aggressiveness of several cancers that includes breast, liver, colon, pancreas, prostate, blood, esophageal, gastro-intestinal etc. Considering its close association with aggressiveness in human cancers, MTA1 may be considered as a potential therapeutic target for cancer treatment. The recent developments in its crystal structure further strengthened the idea of developing small molecule inhibitors for MTA1. In this review, we discuss the recent trends on the diverse functions of MTA1 and its role in various cancers, with the focus to consider MTA1 as a 'druggable' target in the control of human cancers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 95, November 2017, Pages 956-964
Journal: Biomedicine & Pharmacotherapy - Volume 95, November 2017, Pages 956-964
نویسندگان
Vijaya Lakshmi Malisetty, Vasudevarao Penugurti, Prashanth Panta, Suresh Kumar Chitta, Bramanandam Manavathi,