Keywords: FK228 (PubChem CID: 5352062); PXD101 (PubChem CID: 6918638); SAHA (PubChem CID: 5311); LBH-589 (PubChem CID: 6918837); tubacin (PubChem CID: 6675804); tubastatin A (PubChem CID: 49850262); ACY-1215 (PubChem CID: 53340666); ACY-241 (PubChem CID: 53340426);
مقالات ISI (ترجمه نشده)
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Keywords: 5mC; 5- hydroxymethylcytosine; AML; acute myeloid leukemia; BET; bromodomain inhibitors; CCOC; clear cell ovarian cancer; ctDNA; cell-free tumor DNA; ChIP-on-chip; chromatin immunoprecipitation with DNA microarray; CIMP; CpG island methylator phenotype; C
Keywords: Arsenic; Cell Malignant Transformation; Histone Acetylation and Methylation; LC-MS/MS Based Histone Modification Analysis; ac; Acetyl/Acetylated; AGC; Automatic Gain Control; BCa; Bladder Cancer; CID; Collision-Induced Dissociation; DTT; Dithiothreitol; I
Keywords: ac; acetylation; BET; bromodomain and extra terminal family proteins; BMP7; bone morphogenic protein 7; BRD4; bromodomain-containing protein 4; bp; base pairs; CKD; chronic kidney disease; CTGF; connective tissue growth factor; DDR; DNA damage response; D
Keywords: Histone deacetylase inhibitors; Coumarin; 2-AminoBenzamide; Docking; Molecular dynamics; HDAC; Histone Deacetylases; HATs; Histone Acetyl Transferases; HSP 90; Heat Shock Protein 90; SAHA; suberoylanilide hydroxamic acid; TSA; Trichostatin A; ZBG; Zinc Bi
Keywords: HDAC; histone deacetylase; SSRI; selective serotonin reuptake inhibitor; SNRI; serotonin noradrenaline reuptake inhibitor; BDNF; Brain-derived neurotrophic factor; GDNF; glial cell line-derived neurotrophic factor; FEGF; vascular endothelial growth factor
Keywords: Ac-H3; acetylated histone H3; Actb; β-actin; ALS; amyotrophic lateral sclerosis; BA; butyric acid; BA3G; glyceryl tributyrate; b.i.d.; bis in die; CNS; central nervous system; CREB; cAMP responsive element-binding protein; FL-SMN; full-length survival mo
Keywords: Asthma; COPD; DNA methylation; Fibrosis; Histone code; Noncoding RNA; ACD/MPV; alveolar capillary dysplasia and misalignment of pulmonary veins; BMPR2; bone morphogenetic protein receptor 2; COPD; chronic obstructive pulmonary disease; COX-2; cyclooxygena
Keywords: AID/APOBEC; activation-induced cytidine deaminase/apolipoprotein B mRNA-editing enzyme complex; BDNF; brain-derived neurotrophic factor; 5caC; 5-carboxylcytosine; CBP; CREB binding protein; CREB; cAMP response binding protein; DNMT; DNA methyltransferases
Keywords: Histone deacetylases; Histone deacetylases inhibitors; Heart failure; Hypertrophy; DOCA; deoxycorticosterone acetate; HAT; histone acetyltransferases; HDAC; histone deacetylase; HDACi; histone deacetylase inhibitor; MEF2; myocyte enhancer factor-2; MITR;
Keywords: AA; ascorbic acid; ALS; amyotrophic lateral sclerosis; BDNF; brain derived neurotropic factor; BMP; bone morphogenetic protein; DNMT; DNA methyltransferase; EB; embryoid body; EBNA1; Epstein-Barr nuclear antigen-1; ERK; extracellular signal-regulated ki
Keywords: Fear extinction; Exposure therapy; Augmented relearning; Reconsolidation; Drug development; Cognitive enhancer; 5-HT; 5-hydroxytryptamine = serotonin; AC; adenylate cyclase; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMY; amygdala; BA;
Keywords: aceto-HX; acetohydroxamic acid; AS; 3-amino-1,2,4-triazole, Angeli's salt; ATZ; 2,2â²-azino-bis(3-ethylbenzothiazoline-6-sulfonate, ABTS2-; DTNB; 5-5â²-dithio-bis-(2-nitrobenzoic acid); BSA; bovine serum albumin; GSH; glutathione; MbFeIV=O; ferryl m
Keywords: Passive avoidance; Nucleus accumbens; Histone acetylation; 5-AZA; SAHA;
Keywords: AD; Alzheimer's disease; ALD; X-linked adrenoleukodystrophy; ALDRP; adrenoleukodystrophy-related protein; ALDP; adrenoleukodystrophy protein; ALS; amyotrophic lateral sclerosis; ATF-2; activating transcription factor 2; BBB; blood-brain barrier; AP-1; a
Keywords: 1H-NMR; proton nuclear magnetic resonance spectroscopy; 3D; three-dimensional; ANOVA; analysis of variance; APCI; atmospheric pressure chemical ionization; DA; discriminant analysis; DESI; desorption electrospray ionization; DI-MS; desorption ionization
Keywords: ALS; amyotrophic lateral sclerosis; ASO; antisense oligonucleotide; BBB; blood brain barrier; CREB; cyclic AMP response element binding protein; FDA; Food and Drug Administration; GSK-3; glycogen synthase kinase 3; HDAC; histone deacetylase; hnRNP A1; het
Keywords: Cognitive enhancer; Histone deacetylases; Epigenetic; Chromatin; Acetylation; CREB; AcH4K12; acetylated histone H4 lysine 12; AcH3K9; acetylated histone lysine 9; Bdnf; brain-derived neurotrophic factor; CRE; cAMP response element; CREB; cAMP response ele
Keywords: BDNF; brain derived neurotrophic factor; CAMKII; calmodulin-dependent protein kinase II; Ca2+; calcium; cAMP; cyclic adenosine monophosphate; CBS; cystathionine-β-synthase; CCI; chronic constriction injury; CFA; complete Freund's adjuvant; cGMP; cyclic
Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress
Keywords: Znf179; SAHA; HDACs; Oxidative stress; Antioxidants;
HDAC inhibitor suppresses proliferation and invasion of breast cancer cells through regulation of miR-200c targeting CRKL
Keywords: HDAC; histone deacetylase; SAHA; Suberoylanilide Hydroxamic Acid (Vorinostat); miRNA; microRNA; CRKL; Crk-like; EMT; epithelial-mesenchymal transition; Breast cancer; HDAC inhibitor; SAHA; MiR-200c; CRKL;
Histone deacetylase inhibitor (HDACi) upregulates activin A and activates the Smad signaling pathway in melanomas
Keywords: Melanoma; SAHA; R-Smad; Activin A; Secretome;
A series of camptothecin prodrugs exhibit HDAC inhibition activity
Keywords: Camptothecin; HDAC; SAHA; Prodrug;
HDAC inhibitor suppresses proliferation and tumorigenicity of drug-resistant chronic myeloid leukemia stem cells through regulation of hsa-miR-196a targeting BCR/ABL1
Keywords: Chronic myeloid leukemia; Myelogenous leukemia; Hematopoietic stem cells; HDAC inhibition; SAHA; Imatinib; hsa-miR-196a; Chemoresistance;
HDAC11 is a regulator of diverse immune functions
Keywords: APC; antigen presenting cell; CTCL; cutaneous T-cell lymphoma; DAMP; Damage associated molecular pattern; DC; dendritic cell; FDA; U.S. Food and Drug Administration; GVHD; graft versus host disease; HAT; histone acetyltransferase; HDAC; histone deacetylas
HDAC inhibitors as epigenetic regulators for cancer immunotherapy
Keywords: AICD; activation-induced cell death; AML; acute myeloid leukemia; APC; antigen-presenting cells; CAR; coxsackie- and adenovirus receptor; CDKs; cyclin-dependent kinases; CG; cancer germline; DCs; dendritic cells; HAT; histone acetyltransferase; HDAC; hist
Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function
Keywords: Apoptosis; β cells; Inflammation; Lysine demethylases; Gene expression; Diabetes; ATF; Activating transcription factor; ChIP; Chromatin immunoprecipitation; CHOP; C/EBP homologous protein; DP; Death promoting gene; ER; Endoplasmic reticulum; FDH; Formald
SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK-mTOR signalling
Keywords: SAHA; Suberoylanilide hydroxamic acid; AMPK; AMP-dependent protein kinase; HDAC; histone deacetylase; HDACi; Histone deacetylase inhibitor; mTOR; Mechanistic target of rapamycin; NHEJ; Non-homologous end joining; TSA; Trichostatin A; H3K36; Histone H3 lys
Controlled release of an HDAC inhibitor for reduction of inflammation in dry eye disease
Keywords: HDACi; SAHA; Microspheres; PLGA; Dry eye disease;
Functions and epigenetic aspects of miR-15/16: Possible future cancer therapeutics
Keywords: CLL; chronic lymphocytic leukemia; MicroRNAs; miRNAs; UTR; untranslated region; SAHA; suberoyl anilide hydroxamic acid; HDAC; histone deacetylase; miR-15/16; Epigenetics; Drug resistance; Drosha; Therapeutics; EMT;
Design, synthesis and biological screening of 2-aminobenzamides as selective HDAC3 inhibitors with promising anticancer effects
Keywords: B16F10; murine melanoma cells; CDCl3; deuterated chloroform; CTCL; cutaneous T-cell lymphoma; DCM; dichloromethane; DFT; density functional theory; DMAP; 4-Dimethylaminopyridine; DMEM; Dulbecco's modified Eagle's media; DMF; dimethylformamide; DMSO; dimet
Modulating autophagy in cancer therapy: Advancements and challenges for cancer cell death sensitization
Keywords: 3-MA; 3-Methyl Adenine; Akt; Protein kinase B; AMP; Adenosine monophosphate; AMPK; AMP-activated protein kinase; Atg; Autophagy related genes; ATP; Adenosine triphosphate; Bak; Bcl-2 homologous antagonist/killer; Bax; Bcl-2-associated X protein; BCL-2; B-
Suberoylanilide hydroxamic Acid, a histone deacetylase inhibitor, alters multiple signaling pathways in hepatocellular carcinoma cell lines
Keywords: Histone deacetylase inhibitor; SAHA; Vorinostat; Hepatocellular carcinoma; Apoptosis; Notch; AKT; Raf-1; STAT3;
MTA1 expression in human cancers - Clinical and pharmacological significance
Keywords: MTAs; metastasis associated proteins; EMT; epithelial to mesenchymal transition; NuRD; nuclear remodeling and deacetylation complex; HDAC1 or HDAC2; histone deacetylases; MBD; methylated CpG binding domain proteins; RbAb46/48; retinoblastoma associated pr
HMBA is a putative HSP70 activator stimulating HEXIM1 expression that is down-regulated by estrogen
Keywords: HEXIM1; hexamethylene bis-acetamide inducible protein 1; HMBA; hexamethylene bis-acetamide; HSP70; heat shock protein 70; SAHA; suberanilohydroxamic acid; HDAC; histone deacetylases; SDS/PAGE; sodium dodecyl sulfate polyacrylamide gel electrophoresis; FBS
The histone deacetylase inhibitor SAHA simultaneously reactivates HIV-1 from latency and up-regulates NKG2D ligands sensitizing for natural killer cell cytotoxicity
Keywords: HIV-1; Viral latency; LRA; HDACi; SAHA; NK cell; NKG2D; MICA/B; ULBP2;
Synthesis of Vorinostat and cholesterol conjugate to enhance the cancer cell uptake selectivity
Keywords: LDL-receptor; Cancer; SAHA; Cholesterol;
Triggering autophagic cell death with a di-manganese(II) developmental therapeutic
Keywords: γH2AX; phosphorylated H2AX histone; caspase; cysteine-dependent asparate-specific proteases CAT, catalase; CCCP; carbonyl cyanide m-chlorophenyl hydrazine; Dox; doxorubicin; DSB; double strand breaks; LC-3; microtubule associated protein 1 light weight c
SAHA-induced TRAIL-sensitisation of Multiple Myeloma cells is enhanced in 3D cell culture
Keywords: Apoptosis; Cell proliferation; Multiple Myeloma; SAHA; TRAIL; 3D cell culture;
Regulation of the Glycerol Transporter, Aquaporin-3, by Histone Deacetylase-3 and p53 in Keratinocytes
Keywords: AQP; aquaporin; GFP; green fluorescent protein; HDAC; histone deacetylase; SAHA; suberoylanilide hydroxamic acid;
BCL11B-Mediated Epigenetic Repression Is a Crucial Target for Histone Deacetylase Inhibitors in Cutaneous T-Cell Lymphoma
Keywords: CTCL; cutaneous T-cell lymphoma; HDAC; histone deacetylase; HDACi; histone deacetylase inhibitor; IC50; half maximal inhibitory concentration; MF; mycosis fungoides; SAHA; suberoylanilide hydroxamic acid;
Suberoylanilide hydroxamic acid increases progranulin production in iPSC-derived cortical neurons of frontotemporal dementia patients
Keywords: Frontotemporal dementia; iPSCs; Microarray; Neurons; Progranulin; SAHA;
Research ArticleRescue of defective ATP8B1 trafficking by CFTR correctors as a therapeutic strategy for familial intrahepatic cholestasis
Keywords: CFTR; cystic fibrosis transmembrane conductance regulator; 4-PBA; 4-phenyl butyric acid; SAHA; suberoylanilide hydroxamic acid; NB-DNJ; N-butyldeoxynojirimycin; BRIC; benign recurrent intrahepatic cholestasis; PFIC; progressive familial intrahepatic chole
Protection by dietary restriction in the YAC128 mouse model of Huntington's disease: Relation to genes regulating histone acetylation and HTT
Keywords: CBP; Creb binding protein; DR; dietary restriction; HD; Huntington's disease; HTT; mutant huntingtin protein; IGF-1; insulin-like growth factor; Ppp1r1b; DARPP-32; SAHA; suberoylanilide hydroxamic acid; WT; wild-type; Huntington's disease; Dietary restric
The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression
Keywords: Mood disorders; Antidepressants; Animal model of depression; CREB coactivator; BDNF; HDAC inhibitor; SAHA; Epigenetics; Desipramine hydrochloride (PubChem CID: 65327); Vorinostat (PubChem CID: 5311);
A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma
Keywords: SAHA; HDAC inhibitor; FGR; B-cell lymphoma; Drug resistance; BL; Burkitt lymphoma; CC; capture compound; CCMS; capture compound mass spectrometry; CRISPR; Clustered Regularly Interspaced Short Palindromic Repeats; DETECT; drug efficacy testing combined wi
Enhanced efficacy of combined HDAC and PARP targeting in glioblastoma
Keywords: Glioblastoma; Genotoxic stress; DNA repair; SAHA; Olaparib;
Development of a novel in vivo corneal fibrosis model in the dog
Keywords: Alkali burn; Dog; α-smooth muscle actin; Corneal fibrosis; Suberanilohydroxamic acid; SAHA; suberanilohydroxamic acid; α-SMA; α-smooth muscle actin; OCT; optical coherence tomography; IHC; immunohistochemistry; TEM; transmission electron microscropy;
Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism
Keywords: ARE; antioxidant response element; ATP; adenosine triphosphate; 5-hmC; hydroxymethylcytosine; ATG; AuTophaGy related; BNIP; Bcl-2/adenovirus E18 19-kDa-interacting protein; Drp1; dynamin related protein 1; EpRE; electrophile response element; eNOS; endoth
Racemization free longer N-terminal peptide hydroxamate synthesis on solid support using ethyl 2-(tert-butoxycarbonyloxyimino)-2-cyanoacetate
Keywords: Boc-Oxyma; Hydroxamic acid; Peptide hydroxamic acid; Racemization free; SAHA;