کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5553534 1557956 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Salidroside alleviates cigarette smoke-induced COPD in mice
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Salidroside alleviates cigarette smoke-induced COPD in mice
چکیده انگلیسی

The present study was to evaluate the effects of salidroside (Sal) on CS (cigarette smoke)-induced COPD in mice and explore its underlying mechanisms. 50 male ICR mice were randomly assigned to five groups: control group, CS group, CS + dexamethasone (2 mg/kg) group, CS + salidroside (20 mg/kg) group and CS + salidroside (40 mg/kg) group. The COPD mice were induced by CS exposure for 8 weeks. The results of H&E staining demonstrated that Sal alleviated CS-induced pathological injury in lungs. Besides, Sal increased the activities of superoxide dismutase (SOD), reduced the content of malondialdehyde (MDA) in serum. Sal also inhibited the generations of pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) in serum and lungs. Furthermore, the administration of Sal significantly inhibited the protein levels of MAPK/NF-κB pathway in CS-induced mice. Our findings showed that Sal might effectively ameliorate the progression of COPD via MAPK/NF-κB pathway.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 86, February 2017, Pages 155-161
نویسندگان
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