کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5553544 | 1557956 | 2017 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Acute, 28 days sub acute and genotoxic profiling of Quercetin-Magnesium complex in Swiss albino mice Acute, 28 days sub acute and genotoxic profiling of Quercetin-Magnesium complex in Swiss albino mice](/preview/png/5553544.png)
Quercetin-Magnesium complex is one of the youngest alkaline rare earth metal (Magnesium) complexes with flavonoids (Quercetin) in organo-metalic family. Earlier studies describe the details of the complex formation, characterization and antioxidant study of the complex but toxicity profile is still under darkness. The present study was taken up to investigate the oral acute toxicity, 28Â days repeated oral sub-acute toxicity study and genotoxicity study of Quercetin-Magnesium complex in Swiss albino mice. Quercetin-Magnesium complex showed mortality at a dose of 185Â mg/kg in the Swiss albino mice. In 28Â days repeated oral toxicity study, Quercetin-Magnesium complex was administered to both sex of Swiss albino mice at dose levels of 150, 130 and 100Â mg/kg body weight respectively. Where 150Â mg/kg dose shows increased levels of white blood cells and changes in total protein, serum creatinine and blood urea nitrogen. Histopathological study of Quercetin-Magnesium complex shows minor structural alteration in kidney at 150Â mg/kg dose. No observed toxic level found in 130Â mg/kg or below doses. No genotoxic effect found in any doses of the complex. Therefore 130Â mg/kg or below dose level could be better for further study.
Journal: Biomedicine & Pharmacotherapy - Volume 86, February 2017, Pages 279-291