The relationship of plasma decoy receptor 3 and coronary collateral circulation in patients with coronary artery disease

ObjectivePreviously, decoy receptor 3 (DcR3) was found to be a potential angiogenetic factor, while the relationship of DcR3 with coronary collateral circulation formation has not been investigated. In this study, we aimed to investigate whether plasma decoy receptor 3 levels was associated with CCC formation and evaluate its predictive power for CCC status in patients with coronary artery disease.MethodsAmong patients who underwent coronary angiography with coronary artery disease and had a stenosis of ≥ 90% were included in our study. Collateral degree was graded according to Rentrope Cohen classification. Patients with grade 2 or 3 collateral degree were enrolled in good CCC group and patients with grade 0 or 1 collateral degree were enrolled in poor CCC group.ResultsPlasma DcR3 level was significantly higher in good CCC group (328.00 ± 230.82 vs 194.84 ± 130.63 ng/l, p < 0.01) and positively correlated with Rentrope grade (p < 0.01). In addition, plasma DcR3 was also positively correlated with VEGF-A. Both ROC (receiver operating characteristic curve) and multinomial logistical regression analysis showed that plasma DcR3 displayed potent predictive power for CCC status.ConclusionsHigher plasma DcR3 level was related to better CCC formation and displayed potent predictive power for CCC status.