کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5556839 1560545 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of OXCT1 in the pathogenesis of cancer as a rate-limiting enzyme of ketone body metabolism
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
The role of OXCT1 in the pathogenesis of cancer as a rate-limiting enzyme of ketone body metabolism
چکیده انگلیسی

Cancer cells are well documented to reprogram their metabolism in order to support the maintenance and reproduction. 3-oxoacid CoA-transferase 1 (OXCT1) is a key enzyme in ketone body metabolism that catalyzes the first and rate-determining step of ketolysis. The product of OXCT1 converts to acetyl-CoA and finally fed into the tricarboxylic acid cycle for oxidation and ATP production. However, little is known of its regulation right now. Recently, some studies suggested that OXCT1 participates in tumorigenesis and signaling in cancer cells. Furthermore, our recent work showed that a marked elevation of OXCT1 expression in different categories of cancer cells. Here we review the metabolic functions of OXCT1 and its surprising roles in supporting the biological hallmarks of malignancy. We also review recent efforts in exploring the mechanism responsible for the tumor promoting effect of OXCT1 and suggest a novel therapeutic target for cancer therapy.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 183, 15 August 2017, Pages 110-115
نویسندگان
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