کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5557007 1560557 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chronoinflammaging in Alzheimer; A systematic review on the roles of toll like receptor 2
ترجمه فارسی عنوان
آلرژی زا در آلزایمر؛ بررسی سیستماتیک در مورد نقش عوارض مانند گیرنده 2
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

Aging is associated with a range of chronic low-grade inflammation (Chronoinflammaging) which may play a significant role in some chronic inflammatory based diseases, such as Alzheimer disease (AD). However, the events which lead to the induction of chronoinflammaging in AD are yet to be clarified. It has been proposed that the recognition of endogenous ligands by pathogen recognition receptors (PRRs) may be involved in the induction of chronoinflammaging. Toll like receptors (TLRs) are a family of PRRs which recognize endogenous damage associated molecular patterns (DAMPs) and subsequently induce inflammation. Therefore, TLRs are worthy of investigation to elucidate their roles in chronoinflammaging associated AD. This review article explores the main roles played by TLR2 in the pathogenesis of chronoinflammaging in patients suffering from AD.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 171, 15 February 2017, Pages 16-20
نویسندگان
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