کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5557380 1560825 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The ins and outs of calcium signalling in lactation and involution: Implications for breast cancer treatment
ترجمه فارسی عنوان
انسداد و خروج سیگنالینگ کلسیم در شیردهی و پروتئین: اثرات درمان سرطان پستان
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

The mammary epithelium is highly responsive to hormonal and non-hormonal signalling cues for physiological growth, function and tissue remodelling. Whilst steroid hormones freely diffuse across the cell membrane to bind to intracellular hormone receptors, cell-impermeable ligands, including many peptide hormones, growth factors and cytokines, bind to receptors on the plasma membrane and relay their message via the specific activation of intracellular signal transduction pathways. A signalling pathway that is indispensable for decoding many extracellular signals into cellular responses is calcium (Ca2+). Changes in the expression of specific Ca2+ channels, pumps and binding proteins may therefore greatly alter the nature of the cellular response to various growth, morphogenetic and cell death stimuli. This review summarises changes in the expression, localisation and function of key Ca2+ channels and pumps in mammary epithelial cells during lactation and discusses how this altered Ca2+ handling may later expose these cells to targeted cell death during post-lactational involution. A greater understanding of the processes regulating the growth, death and regeneration of the mammary epithelium under physiological conditions may provide important insights into the proliferation and survival mechanisms underpinning malignant growth. The therapeutic manipulation of specific calcium signalling pathways in breast cancer cells to control aberrant cell proliferation and/or turnover represents an aim for the future.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Research - Volume 116, February 2017, Pages 100-104
نویسندگان
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