کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5557510 1560827 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nanoparticles for cancer gene therapy: Recent advances, challenges, and strategies
ترجمه فارسی عنوان
نانو ذرات برای ژن درمان سرطان: پیشرفت های اخیر، چالش ها و استراتژی ها
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

Compared to conventional treatments, gene therapy offers a variety of advantages for cancer treatment including high potency and specificity, low off-target toxicity, and delivery of multiple genes that concurrently target cancer tumorigenesis, recurrence, and drug resistance. In the past decades, gene therapy has undergone remarkable progress, and is now poised to become a first line therapy for cancer. Among various gene delivery systems, nanoparticles have attracted much attention because of their desirable characteristics including low toxicity profiles, well-controlled and high gene delivery efficiency, and multi-functionalities. This review provides an overview on gene therapeutics and gene delivery technologies, and highlight recent advances, challenges and insights into the design and the utility of nanoparticles in gene therapy for cancer treatment.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Research - Volume 114, December 2016, Pages 56-66
نویسندگان
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