کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5557709 1560935 2017 27 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mast cell and eosinophil surface receptors as targets for anti-allergic therapy
ترجمه فارسی عنوان
گیرنده های سطحی مشت سلولی و ائوزینوفیل به عنوان اهداف برای درمان ضد آلرژیک
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

Allergy is the host immune response towards harmless substances, called allergens. Allergic diseases comprise allergic asthma, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and food allergy. While some drugs counteract the symptoms and the inflammation arising from allergy, no completely effective and acceptable side effect free drug has been developed as yet. Moreover, severe asthma and atopic dermatitis are classified as unmet clinical needs. Mast cells and eosinophils are the main effector cells of the allergic response and thus, must be the first cells targeted to impede the allergic inflammation symptoms and evolution. The presence on mast cells and eosinophils of several surface receptors with either activating or inhibitory functions indicates the possibility of their pharmacological targeting. This review deals with some of the receptors expressed on mast cells and eosinophils and their ligand(s). Some receptors have already been exploited as drug targets and others can be feasibly utilized as novel targets for anti-allergic therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 170, February 2017, Pages 37-63
نویسندگان
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