کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5557811 | 1560937 | 2016 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Matrix reloaded: CCN, tenascin and SIBLING group of matricellular proteins in orchestrating cancer hallmark capabilities
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کلمات کلیدی
Tenascin-RMEPEDMP1SPARCIGFBPDSPPTNXANGPTLOPNTNRTenascin-XWISPBSPAP-1Rac1ECMCREBEGFMCPTNCRGDTSPMAPK - MAPKtenascin-C - tenascin-cOsteopontin - استئوپنتینILK - اولThrombospondin - ترومبوزپوندینSibling - خواهر و برادرbone sialoprotein - سیلوپروتئین استخوانepidermal growth factor - عامل رشد اپیدرمیmatrix extracellular phosphoglycoprotein - فسفوگلیکوپروتئین خارج سلولی ماتریکسFibronectin - فیبرونکتینExtracellular matrix - ماتریکس خارج سلولیMatricellular protein - پروتئین Matricellularsecreted protein acidic and rich in cysteine - پروتئین اسیدی و غنی از سیتین را ترشح می کندactivator protein 1 - پروتئین فعال کننده 1dentin matrix protein 1 - پروتئین ماتریکس دنتین 1cAMP-response element-binding protein - پروتئین متصل به عنصر cAMP-responseInsulin-like growth factor-binding protein - پروتئین متصل به پروتئین رشد دهنده انسولینmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenintegrin linked kinase - پیوند کیناز انتگرال
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Matricellular proteins (MCPs) are the non-structural extracellular matrix (ECM) proteins with various regulatory functions. MCPs are critical regulators of ECM homeostasis and are often found dysregulated in various malignancies. They interact with various proteins like ECM structural proteins, integrins, growth factor receptors and growth factors to modulate their availability and activity. Cancer-supporting MCPs are known to induce proliferation, migration and invasion of cancer cells. MCPs also support cancer stem (like) cell growth and induce a drug-resistant state. Apart from their direct effects on cancer cells, they play key roles in angiogenesis, immunomodulation, stromal cell infiltration, stromal proliferation and matrix remodeling. High expression of various MCPs belonging to the tenascin, CCN and SIBLING families is often associated with aggressive tumors and poor patient prognosis. Due to their differential expression and distinct functional role, these MCPs are perceived as attractive therapeutic targets in cancer. Studies on preclinical models have indicated that targeting tumor-supportive MCPs could be a potent avenue for developing anti-cancer therapies. The MCP receptors, like integrins and some associated growth factor receptors, are already being targeted using pharmacological inhibitors and neutralizing antibodies. Neutralizing antibodies against CCNs, tenascins and SIBLINGs have shown promising results in preclinical cancer models, suggesting an opportunity to develop anti-MCP therapies to target cancer. Peptides derived from anti-cancer MCPs could also serve as therapeutic entities. In the present review, in continuation with the expanding horizon of MCP functions and disease association, we focus on (i) their unique domain arrangement, (ii) their association with cancer hallmarks and (iii) available and possible therapeutic interventions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 168, December 2016, Pages 61-74
Journal: Pharmacology & Therapeutics - Volume 168, December 2016, Pages 61-74
نویسندگان
Ravi Thakur, Durga Prasad Mishra,