کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5558436 1561139 2017 30 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Baicalin benefits the anti-HBV therapy via inhibiting HBV viral RNAs
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Baicalin benefits the anti-HBV therapy via inhibiting HBV viral RNAs
چکیده انگلیسی
BA could significantly enhance and reduced HBsAg and HBeAg in hepG2.2.15, a wild-type HBV cell line. Co-treatment of BA and ETV had a more dramatic effect in NA-resistant HBVrtM204V/rtLl80M transfected hepG2 cells. Our study further revealed that BA mainly inhibited the production of HBV RNAs (3.5, 2.4, 2.1 kb), the templates for viral proteins and HBV-DNA synthesis. BA blocked HBV RNAs transcription possibly by down-regulating transcription and expression of HBV replication dependent hepatocyte nuclear factors (HNF1α and HNF4α). Thus, BA may benefit the anti-HBV therapy via inhibiting HBV viral RNAs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 323, 15 May 2017, Pages 36-43
نویسندگان
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