کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5559813 1561693 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ecotoxicity of veterinary enrofloxacin and ciprofloxacin antibiotics on anuran amphibian larvae
ترجمه فارسی عنوان
اکوتوکسی سمیت انوفلوکساسین دامپزشکی و آنتی بیوتیک های سایپروفلوکساسین در لارو دوزیستان انوران
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- Risk characterization was performed for Enrofloxacin (EFX) and Ciprofloxacin (CPX).
- Biological responses (development, growth and oxidative stress enzymes) were analyzed.
- Fluoroquinolones had negative effects on Rhinella arenarum biological endpoints.
- Environmental release of EFX and CPX pose risks for Rhinella arenarum tadpoles.
- Antibiotics in waterbodies are a threat for aquatic organisms.

The ecological risks posed by two β-diketone antibiotics (DKAs, enrofloxacin, ENR and ciprofloxacin, CPX), characterized by their long persistence in aqueous environments and known deleterious effect on model organisms such as zebrafish were analysed using Rhinella arenarum larvae. Sublethal tests were conducted using environmentally relevant concentrations of both ENR and CPX (1-1000 μg L−1) under standard laboratory conditions for 96 h. Biological endpoints and biomarkers evaluated were body size, shape, development and growth rates, and antioxidant enzymes (glutathione-S-transferase, GST; Catalase, CAT). Risk assessment was analysed based on ration quotients (RQ). The size and shape measurements of the larvae exposed to concentrations greater than 10 μg L−1 of CPX were lower compared to controls (Dunnett post hoc p < 0.05) and presented signs of emaciation. Concentrations of 1000 μg L−1of CPX induced GST activity, in contrast with inhibited GST and CAT of larvae exposed to ENR. Risk assessments indicated that concentrations greater than or equal to10 μg L−1 of CPX and ENR are ecotoxic for development, growth, detoxifying, and oxidative stress enzymes. It is suggested that additional risk assessments may provide evidence of bioaccumulation of CPX and ENR in tissues or organs of amphibian larvae by mesocosm sediment test conditions. Finally, intestinal microbiome studies should be considered to establish the mechanisms of action of both antibiotics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 51, April 2017, Pages 114-123
نویسندگان
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