کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5560020 1403306 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hepatoprotective activities of rosmarinic acid against extrahepatic cholestasis in rats
ترجمه فارسی عنوان
فعالیت های محافظتی ضد التهابی اسید رزمارینیک در برابر کلستاز خارق العاده در موش صحرایی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی


- Bile duct ligation caused extrahepatic cholestasis in rodents.
- Rosmarinic acid showed improvement effects against cholestasis.
- Rosmarinic acid attenuated hepatic TGF-β1 signaling in BDL rats.
- Rosmarinic acid attenuated hepatic NF-κB/AP-1 activities in BDL rats.
- Rosmarinic acid attenuated hepatic HMGB1/TLR4 signaling in BDL rats.

Though rosmarinic acid possesses nutritional, pharmaceutical, and toxic properties and shows therapeutic potential on liver diseases, its therapeutic effects against cholestatic liver diseases have not been proven. Using an extrahepatic cholestasis rat model by bile-duct ligation (BDL), daily oral administration of rosmarinic acid showed improvement effects on liver histology, serum biochemicals, ductular reaction, oxidative stress, inflammation, and fibrosis. Rosmarinic acid alleviated BDL-induced transforming growth factor beta-1 (TGF-β1) production and hepatic collagen deposition, and the anti-fibrotic effects were accompanied by reductions in matrix-producing cells and Smad2/3. BDL rats showed increased hepatic NF-κB/AP-1 activities, inflammatory cell infiltration/accumulation, and cytokine production, and these signs of hepatic inflammation were ameliorated by rosmarinic acid. Mechanistic study revealed an inhibitory effect of rosmarinic acid on the axis of the high mobility group box-1 (HMGB1)/toll-like receptor-4 (TLR4) in BDL rats. Results of cultured hepatic stellate cells further showed the impacts of rosmarinic acid which attenuated TGF-β1-induced stellate cell mitogenic and fibrogenic activation. Our findings support the concept that rosmarinic acid could serve as a hepatoprotective agent, and dietary rosmarinic acid supplementation may be beneficial in terms of improving cholestasis-related liver injury via mechanisms involving resolution of oxidative burden and down-regulation of HMGB1/TLR4, NF-κB, AP-1, and TGF-β1/Smad signaling.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 108, Part A, October 2017, Pages 214-223
نویسندگان
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