کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5561124 1562113 2017 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cleaning and asthma: A systematic review and approach for effective safety assessment
ترجمه فارسی عنوان
تمیز کردن و آسم: بررسی و رویکرد سیستماتیک برای ارزیابی ایمنی موثر است
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- An updated systematic review of epidemiology studies leaves unresolved the basis for causal links with asthma.
- A data integration and hazard characterization system for asthma risk assessment is presented.
- The approach is demonstrated with an acetic acid ingredient case study.

Research indicates a correlative relationship between asthma and use of consumer cleaning products. We conduct a systematic review of epidemiological literature on persons who use or are exposed to cleaning products, both in occupational and domestic settings, and risk of asthma or asthma-like symptoms to improve understanding of the causal relationship between exposure and asthma. A scoring method for assessing study reliability is presented. Although research indicates an association between asthma and the use of cleaning products, no study robustly investigates exposure to cleaning products or ingredients along with asthma risk. This limits determination of causal relationships between asthma and specific products or ingredients in chemical safety assessment. These limitations, and a lack of robust animal models for toxicological assessment of asthma, create the need for a weight-of-evidence (WoE) approach to examine an ingredient or product's asthmatic potential. This proposed WoE method organizes diverse lines of data (i.e., asthma, sensitization, and irritation information) through a systematic, hierarchical framework that provides qualitatively categorized conclusions using hazard bands to predict a specific product or ingredient's potential for asthma induction. This work provides a method for prioritizing chemicals as a first step for quantitative and scenario-specific safety assessments based on their potential for inducing asthmatic effects. Acetic acid is used as a case study to test this framework.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 90, November 2017, Pages 231-243
نویسندگان
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