کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5561277 1562117 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Behaviour of chemical respiratory allergens in novel predictive methods for skin sensitisation
ترجمه فارسی عنوان
رفتار الکل های شیمیایی تنفسی شیمیایی در روش های پیش بینی جدید برای حساسیت پوست
کلمات کلیدی
آلرژن های شیمیایی تنفسی، حساسیت پوستی، تستهای پیش بینی شده، شناسایی خطر،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- Chemical respiratory allergens test positive in in vivo skin sensitisation assays.
- The performance of such allergens in in vitro skin sensitisation tests is examined.
- Correlations were good, but not perfect, and there remain gaps to be filled.

Asthma resulting from sensitisation of the respiratory tract to chemicals is an important occupational health issue, presenting many toxicological challenges. Most importantly there are no recognised predictive methods for respiratory allergens. Nevertheless, it has been found that all known chemical respiratory allergens elicit positive responses in assays for skin sensitising chemicals. Thus, chemicals failing to induce a positive response in skin sensitisation assays such as the local lymph node assay (LLNA) lack not only skin sensitising activity, but also the potential to cause respiratory sensitisation. However, it is unclear whether it will be possible to regard chemicals that are negative in in vitro skin sensitisation tests also as lacking respiratory sensitising activity. To address this, the behaviour of chemical respiratory allergens in the LLNA and in recently validated non-animal tests for skin sensitisation have been examined. Most chemical respiratory allergens are positive in one or more newly validated non-animal test methods, although the situation varies between individual assays. The use of an integrated testing strategy could provide a basis for recognition of most respiratory sensitising chemicals. However, a more complete picture of the performance characteristics of such tests is required before specific recommendations can be made.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 86, June 2017, Pages 101-106
نویسندگان
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