کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5562003 | 1562591 | 2017 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Early postnatal exposure to endosulfan interferes with the normal development of the male rat mammary gland
ترجمه فارسی عنوان
قرار گرفتن در معرض آندوسولفان قبل از زایمان، با پیشرفت طبیعی غدد رحم موش صحرایی مواجه است
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کلمات کلیدی
Terminal end budsPNDIODEDCs - EDC هاEsr1 - ESR1Endosulfan - آندوسولفانEstradiol - استرادیولendo - اندوintegrated optical density - تراکم نوری یکپارچهtestosterone - تستوسترونpostnatal day - روز پس از زایمانMammary gland - غده شیریEndocrine-disrupting chemicals - مواد شیمیایی خرابکار غدد درون ریزMale - نرHypertrophy - هیپرتروفی یا پُرسازیhyperplasia - هیپرپلازی، بیش رویش، هایپرجنزیCollagen - کلاژنLymph node - گره های لنفاویAndrogen Receptor - گیرنده آندروژنیEstrogen receptor alpha - گیرنده استروژن آلفا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Our aim was to evaluate whether postnatal exposure to endosulfan (ENDO) modifies mammary gland (MG) development in pre- and post-pubertal male rats. From postnatal day 1 (PND1) to PND7, male rats were injected subcutaneously every 48 h with either corn oil (vehicle) or 600 μg ENDO/kg.bw. On PND21 and PND60, MG and blood samples were collected. Estradiol (E2) and testosterone (T) serum levels, MG histology, collagen fiber organization, proliferation index, and estrogen (ESR1) and androgen receptor (AR) expressions were evaluated. On PND21, E2 and T levels were similar between groups, whereas MG area, perimeter, number of terminal end buds and ESR1 expression were increased in ENDO-exposed rats. These changes were associated with alveolar development and increased organized collagen in the stroma. On PND60, a higher proliferation index in ENDO-exposed rats was correlated with a more developed lobuloalveolar structure. Hyperplastic alveoli and, hyperplastic ducts surrounded by a dense stroma were also observed in this group. T levels and ESR1 expression were similar between groups, whereas E2 levels and AR expression were decreased in ENDO-exposed rats. The exposure to ENDO in the first week of life interferes with the normal development of the MG and induces pre-malignant lesions in post-pubertal male rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 281, 5 November 2017, Pages 102-109
Journal: Toxicology Letters - Volume 281, 5 November 2017, Pages 102-109
نویسندگان
Gabriela A. Altamirano, Melisa B. Delconte, Ayelen L. Gomez, Ramiro Alarcón, Verónica L. Bosquiazzo, Enrique H. Luque, Mónica Muñoz-de-Toro, Laura Kass,